Biological Research | Glavy Lab

Welcome to the Glavy Lab!

We study Nuclear Pore Complexes (NPCs) and proteins associated in DNA damage response pathways. Our work utilizes a variety of cell lines to explore these topics and we also implement a broad range of techniques, including confocal microscopy, western blotting, ultracentrifugation, and live cell imaging.

Our lab is located in the Department of Pharmaceutical Sciences at the University of Texas at Tyler. Tyler is a medium-sized town nestled in the piney woods of east Texas, approximately an hour and a half east of Dallas. Tyler is known as the Rose Capital of America and produces beautiful roses and azaleas in the spring. It's also a great place to conduct research! To find out more about our lab location, click here.

The personnel working in our lab all come from different backgrounds and have their sights set on different career paths. Our pharmacy students even have their own projects, so as to enhance their training as they progress through the pharmacy program. To learn more about our personnel and their daily routines, click here!

If you are interested in learning more about our lab or want to become part of the team, please contact Joseph Glavy.

Day in the Life of Lab Technician:

Ben Jordan

Principles of Confocal Microscopy:

See remaining parts and techniques here.

Dr. Glavy has been cited over a thousand times (Web of Science) - Most Cited Works

Kosinski, J., Mosalaganti. S., Von Appen, A., Teimer, R., DiGuilio A.L., Wan, W., Bui, K.H. , Andres-Pons, A., Hagen, W., Briggs, J.A.G., Glavy, J.S., Hurt, E. , Beck, M. (2016) Molecular architecture of the inner ring scaffold of the human nuclear pore complex Science 352(6283):363-5. PMID: 27081072. Citations:139

Von Appen, A., Kosinski, J., Sparks, L., Ori A., DiGuilio A.L., Vollmer, B., Mackmull, M.T., Banterle, N., Parca, L., Kastritis, P., Buczak, K., MosalagantI, S., Hagen, W., Andres-Pons, A., Lemke, E.A., Bork, P., Antonin, W., Glavy, J.S., Bui, K.H. , Beck, M. (2015) In Situ Structural Analysis of the Human Nuclear Pore Complex. Nature 526(7571):140-3 PMID: 26416747. Citations:173

Bui, K.H., Von Appen, A., DiGuilio, A.L., Ori, A., Sparks, L., Mackmull, M.T., Bock, T., Hagen, W., Andres-Pons, A., Glavy, J.S.*, Beck, M.* (2013) Integrated structural analysis of the human nuclear pore complex scaffold. Cell.155(6):1233-43. PMID: 24315095. Citations:198

Blethrow, J.D., Glavy, J.S., Morgan D.O., and Shokat, K.M. (2008) Covalent Capture of Kinase-specific Phosphopeptides reveals Cdk1-cyclin B substrates. PNAS 105:1442-7 PMID: 18234856. Citations:214

News

February 2020: Congratulations to Michelle & Dr. Glavy for their chapter published in "The Liver: Biology and Pathobiology 6th Edition."

DETAILS

August 2019: See Ben's first publication in Nucleic Acids Research.