Welcome to the Glavy Lab!
We study Nuclear Pore Complexes (NPCs) and proteins associated in DNA damage response pathways. Our work utilizes a variety of cell lines to explore these topics and we also implement a broad range of techniques, including confocal microscopy, western blotting, ultracentrifugation, and live cell imaging.
Our lab is located in the Department of Pharmaceutical Sciences at the University of Texas at Tyler. Tyler is a medium-sized town nestled in the piney woods of east Texas, approximately an hour and a half east of Dallas. Tyler is known as the Rose Capital of America and produces beautiful roses and azaleas in the spring. It's also a great place to conduct research!
If you are interested in learning more about our lab or want to become part of the team, please contact Joe Glavy.
If you want to find out more click on :
The Art of Early Microscopes
Day in the Life of Lab Technician:
Blethrow, J.D., DiGuilio, A.L. and Glavy, J.S. (2022) Purification of Cdk-CyclinB-Kinase-Targeted Phosphopeptides from Nuclear Envelope. Methods in Molecular Biology 2502:271-282.
Jordan, B.R.*, Zhu, Y., Li, Z, Zhao, H., Mackmull, M.T., Glavy J.S. (2023) Discovering the Nuclear Localization Signal of Werner Helicase Interacting Protein 1. Biochim Biophys Acta. 2023 (In Press) BBAMCR-23-150R1
Lizarraga, A., Hart. L., Nolen, M., Williams, L.R., Glavy, J.S. (2023) Incidents of snake fungal disease caused by the fungal pathogen Ophidiomyces ophidiicola in Texas. Front. Fungal Biol., 4, https://doi.org/10.3389/ffunb.2023.1064939
Dr. Glavy has been cited over a thousand times (Web of Science) - Most Cited Works
Kosinski, J., Mosalaganti. S., Von Appen, A., Teimer, R., DiGuilio A.L., Wan, W., Bui, K.H. , Andres-Pons, A., Hagen, W., Briggs, J.A.G., Glavy, J.S., Hurt, E. , Beck, M. (2016) Molecular architecture of the inner ring scaffold of the human nuclear pore complex Science 352(6283):363-5. PMID: 27081072.
Von Appen, A., Kosinski, J., Sparks, L., Ori A., DiGuilio A.L., Vollmer, B., Mackmull, M.T., Banterle, N., Parca, L., Kastritis, P., Buczak, K., MosalagantI, S., Hagen, W., Andres-Pons, A., Lemke, E.A., Bork, P., Antonin, W., Glavy, J.S., Bui, K.H. , Beck, M. (2015) In Situ Structural Analysis of the Human Nuclear Pore Complex. Nature 526(7571):140-3 PMID: 26416747.
Bui, K.H., Von Appen, A., DiGuilio, A.L., Ori, A., Sparks, L., Mackmull, M.T., Bock, T., Hagen, W., Andres-Pons, A., Glavy, J.S.*, Beck, M.* (2013) Integrated structural analysis of the human nuclear pore complex scaffold. Cell.155(6):1233-43. PMID: 24315095.
Blethrow, J.D., Glavy, J.S., Morgan D.O., and Shokat, K.M. (2008) Covalent Capture of Kinase-specific Phosphopeptides reveals Cdk1-cyclin B substrates. PNAS 105:1442-7 PMID: 18234856.