Welcome to the Glavy Lab!
We study Nuclear Pore Complexes (NPCs) and proteins associated with DNA damage response pathways. Our work utilizes a variety of cell lines to explore these topics, and we also implement a broad range of techniques, including confocal microscopy, western blotting, ultracentrifugation, and live cell imaging. Our most recent project focuses on characterizing the structures within the nucleus and how they change throughout mitosis in lower eukaryotes. This work uses genome-resolved multi-Omics methods paired with high-resolution imaging.
Our lab is located in the Department of Pharmaceutical Sciences at the University of Texas at Tyler. Tyler is a medium-sized town nestled in the piney woods of east Texas, approximately an hour and a half east of Dallas. Tyler is known as the Rose Capital of America and produces beautiful roses and azaleas in the spring. It's also a great place to conduct research!
If you are interested in learning more about our lab or want to become part of the team, please contact Joe Glavy.
The Art and Design of the Early Compound Microscopes.
Dr. Glavy has been an annual speaker for World Microscope Day, April 13th.
American Society for Cell Biology (ASCB)
Dr. Glavy has been appointed as the Co-Chair of the Public Information Committee (2024-2026).
If you want to find out more click on :
Lab Members
Lab Techniques
Confocal Images
The Art of Early Microscopes
Day in the Life of Lab Technician:
Ben Jordan
Recent Publications
Glavy, J.S. (2024) The yin and yang of nuclear envelope breakdown through the activity of phosphatase holoenzyme PP2A-B55SUR-6. Trends Cell Biol. S0962-8924(24)00019-9. doi: 10.1016/j.tcb.2024.01.007.
Jordan, B.R. , Zhai, Y., Li, Z., Zhao, H., Mackmull, M.-T., Glavy, J.S. (2023) Discovering the nuclear localization signal of Werner Helicase Interacting Protein 1, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1870, 119502.
Lizarraga, A., Hart. L., Nolen, M., Williams, L.R., Glavy, J.S. (2023) Incidents of snake fungal disease caused by the fungal pathogen Ophidiomyces ophidiicola in Texas. Front. Fungal Biol., 4, https://doi.org/10.3389/ffunb.2023.1064939
Blethrow, J.D., DiGuilio, A.L. and Glavy, J.S. (2022) Purification of Cdk-CyclinB-Kinase-Targeted Phosphopeptides from Nuclear Envelope. Methods in Molecular Biology 2502:271-282.
Educational Publication
Oshair, O., Veronin, M., Smith, W., Adelaziz, M., Glavy, J.S., and Pirtle, S.J. (2023) Pharmacy students’ perceptions and attitudes toward face-to-face vs. virtual team-based learning (TBL) in the didactic curriculum: A mixed-methods study. Medical Education Online (ZMEO) ZMEO 2226851.
Principles of Confocal Microscopy:
See remaining parts and techniques here.
Dr. Glavy has been cited over a thousand times (Web of Science) - Most Cited Works
Kosinski, J., Mosalaganti. S., Von Appen, A., Teimer, R., DiGuilio A.L., Wan, W., Bui, K.H. , Andres-Pons, A., Hagen, W., Briggs, J.A.G., Glavy, J.S., Hurt, E. , Beck, M. (2016) Molecular architecture of the inner ring scaffold of the human nuclear pore complex Science 352(6283):363-5. PMID: 27081072.
Von Appen, A., Kosinski, J., Sparks, L., Ori A., DiGuilio A.L., Vollmer, B., Mackmull, M.T., Banterle, N., Parca, L., Kastritis, P., Buczak, K., MosalagantI, S., Hagen, W., Andres-Pons, A., Lemke, E.A., Bork, P., Antonin, W., Glavy, J.S., Bui, K.H. , Beck, M. (2015) In Situ Structural Analysis of the Human Nuclear Pore Complex. Nature 526(7571):140-3 PMID: 26416747.
Bui, K.H., Von Appen, A., DiGuilio, A.L., Ori, A., Sparks, L., Mackmull, M.T., Bock, T., Hagen, W., Andres-Pons, A., Glavy, J.S.*, Beck, M.* (2013) Integrated structural analysis of the human nuclear pore complex scaffold. Cell.155(6):1233-43. PMID: 24315095.
Blethrow, J.D., Glavy, J.S., Morgan D.O., and Shokat, K.M. (2008) Covalent Capture of Kinase-specific Phosphopeptides reveals Cdk1-cyclin B substrates. PNAS 105:1442-7 PMID: 18234856.
The Liver: Biology and Pathobiology 6th Edition
ISBN-13: 978-1119436829
Veronin, M.A. & Glavy, J.S. (2020) The Nuclear Pore Complex. Ch. 9, pgs. 94-107. The Liver: Biology and Pathobiology. John Wiley & Sons Press.
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Our research is funded by National Science Foundation (NSF) grant 1914538, National Institute of Health, National Institute of General Medical Sciences (NIH NIGMS) grant 1R15 GM119118 and National Institute on Aging (NIH NIA) 1R21AG047433.
Out Our Lab Location
